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Report | Regular issue | Vol 20, No. 12, 1983, pp.2429-2431
Published online, 1st January, 1970
DOI: 10.3987/R-1983-12-2429
A Facile Synthesis of 1,3-Dialkyl-5-fluororacils by Means of Phase Transfer Catalysis

Tomonori Hoshiko, Yutaka Watanabe, and Shoichiro Ozaki

*Faculty of Engineering, Ehime University, 3 Bunkyo-cho, Matsuyama, 790-8577 Ehime, Japan


The reaction of 5-fluorouracil with an alkyl halide in the presence of a phase transfer catalyst and potassium hydroxide gives 1,3-dialkyl-5-fluorouracil in good yield.