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Communication | Regular issue | Vol 22, No. 3, 1984, pp.473-477
Published online, 1st January, 1970
DOI: 10.3987/R-1984-03-0473
Structures of Mulberrofurans F and G, Two Natural Hypotensive Diels-Alder Type Adducts from the Cultivated Mulberry Tree (Morus lhou (ser.) Koidz.)

Toshio Fukai, Yoshio Hano, Kazuhiro Hirakura, Taro Nomura,* Jun Uzawa, and Kazutaka Fukushima

*Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

From ethyl acetate extract of the root bark of cultivated mulberry tree (Morus Lhou(ser.) Koidz.), two 2-arylbenzofuran derivatives were isolated and named mulberrofurans F and G, whose structures were shown to be 1 and 2, respectively, on the basis of spectral and chemical evidences. Mulberrofurans F (1) and G (2) were derived from chalcomoracin (3) and mulberrofuran C (4), respectively, by the photocyclization in the acidic solution. Intravenous injection of mulberrofurans F (1), as well as G (2), caused a marked depressor effect in rabbit.