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Report | Regular issue | Vol 22, No. 3, 1984, pp.501-504
Published online, 1st January, 1970
DOI: 10.3987/R-1984-03-0501
Reactions of 4-Pyrimidinone Derivatives with Methyl Isocyanate: Formation of Pyrimido[1,2-a][1,3,5]triazine-2,4-dione RIng System

Masami Sawada, Yoshiro Furukawa, Yoshio Takai, and Terukiyo Hanafusa*

*The Institute of Scientific and Industrial Research, Osaka University ,8-1, Mihogaoka, Ibaraki, Osaka 567-0047, Japan


Base-catalysed reactions of 4-pyrimidinone and 4-quinazolinone with methyl isocyanate gave the compounds with a pyrimido[1,2-a][1,3,5]triazine-2,4-dione ring system (3 and 5, respectively; 1:2-cyclic adducts). In contrast, some uracil derivatives afforded the 1-methylcarbamoyl compounds (7, 1:1-adducts) .