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Report | Regular issue | Vol 22, No. 4, 1984, pp.749-761
Published online, 1st January, 1970
DOI: 10.3987/R-1984-04-0749
Enzymatic "in vitro" Reductions of Ketones. Part 12. Reduction of 1-Alkyl-4-piperidones in an Ethanol-NAD+-HLAD-system

Jaymes Van Luppen, Jozef Lepoivre, Guy Lemière, and Frank Alderweireldt

*Labratory of Organic Chemistry, University of Antwerp (RUCA), Groenenborgerlaan 171, B-2020 Antwerp, Belgium


The steady state initla1 rate equation for a ketone-ethanol-NAD+-HLAD recycling system is checked for 1-n-butyl-4-piperidone. All reaction parameters are discussed in order to optimize the reduction of this substrate. For a series of 1-alkyl-4-piperidones the thermodynamic activation parameters for the reduction in this system are determined and discussed.