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■ 1,2,3,5,6,10b-Hexahydropyrrolo[2,1-a]isoquinolines. Preparation and Stereochemistry of 3-Benzyl Derivatives

Joan Bosch,* Esther Mestre, Josep Bonjoch, Francisco López, and Ricardo Grandos

*Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. de Joan XXIII, s/n, 08028 Barcelona, Spain

Abstract

The preparation of cis- and trans-3-benzyl-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolines 1 and 2 and the preferred conformation of the indolizidine ring system of these compounds are reported.