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Report | Regular issue | Vol 22, No. 4, 1984, pp.779-783
Published online, 1st January, 1970
DOI: 10.3987/R-1984-04-0779
Modified Bleomycins. Synthesis of New Bleomycins via Reaction of Demethyl-BLM A2 with Bromoacetyl Derivatives

Wilhelmus J. Vloon, Cornelis Kruk, Upendra K. Pandit,* Hendricus P. Hofs, and John G. McVie

*Organic Chemistry Department, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands

Abstract

Reaction of demethyl-BLM A2 with bromoacetyl derivatives leads to the corresponding sulfonium salts which constitute a new class of biologically active bleomycins.