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Report | Regular issue | Vol 22, No. 4, 1984, pp.785-790
Published online, 1st January, 1970
DOI: 10.3987/R-1984-04-0785
Synthesis of Cyclo-N-methyl-L-tyr-N-methyl-L-tyr-D-ala-L-ala-O,N-dimethyl-L-tyr-L-ala, a Cyclic Hexapeptide Related to the Antitumor Agent Deoxybouvardin

Robert B. Bates,* Susan L. Gin, Mark A. Hassen, Victor J. Hruby, Kim D. Janda, George R. Kriek, Jon-Pierre Michaud, and Daniel B. VIne

*Department of Chemistry, The University of Arizona, Tucson, Arizona 85721, U.S.A.

Abstract

A synthesis of the title cyclic hexapeptide is described. Its lack of antitumor activity shows That the 14-membered ring of deoxybouvardin is needed for activity. Efforts to oxidatively couple its phenolic groups failed to give deoxybouvardin.