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Report | Regular issue | Vol 22, No. 5, 1984, pp.1105-1114
Published online, 1st January, 1970
DOI: 10.3987/R-1984-05-1105
Preparation of Fluoroheterocycles I. Synthesis and Reactivity of 2-Fluoropyrazine 1-Oxide

Misa V. Jovanovic*

*Department of Chemistry, Southern Methodist University, P.O. Box 750314, Dallas, TX 75275-0314, U.S.A.


The title compound was prepared by three different methods: Balz-Schiemann reaction, halogen exchange, and by direct N-oxidation of 2-fluoropyrazine. The resulting 2-fluoro- pyrazine 1-oxide was reacted with a variety of nucleophiles to yield the corresponding 2-substituted pyrazine 1-oxides.