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Report | Regular issue | Vol 22, No. 8, 1984, pp.1747-1757
Published online, 1st January, 1970
DOI: 10.3987/R-1984-08-1747
An Improved Synthesis of 2-Methyl-4-(2’-carboxyethyl)pyrrole. Potential Inhibitors of Porphobilinogen Deaminase

Samuel H. Wilen,* DeKang Shen, Joseph M. Licata, Enoch Baldwin, and Charlotte S. Russell

*Department of Chemistry, The City College of the City University of New York, Convent Avenue @ 138th Street, New York, NY 10031, U.S.A.

Abstract

Improved syntheses of 2-methyl-4-(2’-carboxyethyl)pyrrole (10) (49% overall yield) and of several O- and S-containing β-(5-ring heterocyclic)-substituted propionic acids are described. Some of these compounds have been found to be inhibitors of porphobilinogen deaminase.