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Report | Regular issue | Vol 22, No. 11, 1984, pp.2575-2579
Published online, 1st January, 1970
DOI: 10.3987/R-1984-11-2575
Direct α-Bromination of Morphinan-6-one Bases

Yoshiro K. Sawa, Masaaki Kobayashi, and Haruhiko Tada*

*Shionogi Research Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan


Bromination of morphinan-6-one base in the presence of HBr afforded α-bromoketone without aromatic substitution. This method may be applicable to other basic compounds, such as alkaloids, except for compounds having acid-sensitive functional groups.