HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Synthesis of N-Substituted 1,6-Dihydro-3(2H)-pyridinones and 1-Acyl-3-piperidines

Ling-Ching Chen,* Eng-Chi Wang, Jen-Hom Lin, and Shihn-Sheng Wu

*Graduate Institute of Natural Products, Kaohsiung Medical College, 100 Shih Chuen 1st Rd., Kaohsiung 80708, Taiwan, R.O.C.

Abstract

Synthesis of the N-substituted 1,6-dihydro-3(2H)-pyridinones (3, 6, and 9) and 1-acyl-3-piperidones (7 and 10) is described. 1-Benzylpiperidine-3,5-dione (1) was converted into N-substituted 1,6-dihydro-3(2H)-pyridinones (3, 6, and 9) via the methyl enol ethers (2, 5, and 8). Selective reduction of 6 and 9 with Et₃SiH in the presence of TiCl₄ produced the 1-acyl-3-piperidones (7 and 10).