HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Novel Heterocycles. 11. Synthesis of the Spiro[pyrrolidine-3,2’(1’H)-quinazoline]ring System

Gary M. Coppola* and Michael J. Shapiro

*Sandoz Research Institute, Sandoz, Inc., Route 10, East Hanover, New Jersey 07936, U.S.A.

Abstract

The reaction of amines with 1 and 2 was investigated. When 1 or 2 was treated with ammonia only the monoamide 3 was formed. An analogous reaction of 2 with methylamine produced the diamide 4 whereas 1 yielded the spiro imide 6 contaminated with minor amounts of 4. Compound 6 was also obtained from the alkylation of 3 with methyl iodide. The reaction of equimolar amounts of 2 and benzylamine furnished the spiro imide 5. Some spectral data, including carbon-13 assigments, are also discussed.