Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 23, No. 1, 1985, pp.21-24
Published online, 1st January, 1970
DOI: 10.3987/R-1985-01-0021
1-Ethyl-3-methylisoguanosine, a Doridosine Derivative

Yong Hae Kim,* Sang Joa Jee, and Harry S. Mosher

*Department of Applied Chemistry, Korea Advanced Institute of Science and Technology, P.O.Box 150 Chong-Yang-ni, Seoul 131, Korea


1-Ethyl-6-imino-3-methyl-2-oxo-9-β-D-ribofuranosylpurine (2, 1-ethyl-3-methyl-isoguanosine) has been synthesized from 5-(methylamino)-1-β-D-ribofuranosylimidazole-4-carbonitrile. This modified purine, by virtue of substituents on both N1 and N3 nitrogens is frozen in the 6-imino form; its uv spectrum is compared to that of analogs which can exist in the tautomeric 6-amino ⇔ 6-imino forms. It is relatively stable to hydrolysis of the 9-ribosyl bond in contrast to other N3-substituted nucleosides.