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Report | Regular issue | Vol 23, No. 3, 1985, pp.611-616
Published online, 1st January, 1970
DOI: 10.3987/R-1985-03-0611
The Synthesis and Aminolysis of Some 4-Chloro-2-(substituted) Thiopyrimidines

Derek T. Hurst* and Matthew Johnson

*School of Analytical and Biological Chemistry, Kingston Polytechnic, Kingston-on-Thames, KT1 2EE, U.K.

Abstract

Some 2-methylthio,2-methylsulphinyl and 2-methylsulphonyl-4-chloropyrimidines have been prepared. In each case which was studied except one the chloride ion was that which was preferentially displaced by diethylamine. The pseudo first order rate constant for each reaction was determined the results showing that oxidation of the 2-methylthio group greatly enhances the rate of displacement of the 4-chloro group.