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Communication | Regular issue | Vol 23, No. 5, 1985, pp.1081-1084
Published online, 1st January, 1970
DOI: 10.3987/R-1985-05-1081
Facile Retro Dieckmann Reaction of 3-Oxo-carbapenam Esters

Johannes G. de Vries,* Gerhard Hauser, and Gerfard Sigmund

*Sandoz Forschungsinstitut, 1235 Wien, Brunnerstraße 59, Austria


Bicyclic ketones 1b and 1c reacted with nucleophiles to give azetidinones 4. Azetidinone 4a was deprotected to give 5, which was antibacterially inactive.