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Communication | Regular issue | Vol 23, No. 5, 1985, pp.1107-1110
Published online, 1st January, 1970
DOI: 10.3987/R-1985-05-1107
A New Synthetic Method for Proline Derivatives via the Azomethine Ylide Intermediate Generated from Methyl N-(Trimethylsilylmethyl)iminoacetate

Nobuyuki Imai, Yoshiyasu Terao, and Kazuo Achiwa*

*Schol of Pharmaceutical Sciences, Schol of Pharmaceutical Sciences, 52-1 Yada, Shizuoka 422-8526, Japan


Proline derivatives were found to be synthesized by the 1,3-dipolar cycloaddition of the azomethine ylide, produced from methyl N-(trimethylsilylmethyl)iminoacetate and benzyl bromide or a catalytic amount of trifluoroacetic acid, to conjugated olefins.