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Communication | Regular issue | Vol 23, No. 8, 1985, pp.1915-1919
Published online, 1st January, 1970
DOI: 10.3987/R-1985-08-1915
Synthesis of Carbaoenems with a RXCH2-Substituent in the 3-Position

Johannes G. de Vries,* Gerhard Sigmund, and Georg Vorisek

*Sandoz Forschungsinstitut, 1235 Wien, Brunnerstraße 59, Austria

Abstract

Carbapenems 6 were prepared by reacting mercaptans with bromoketone 3 followed by a Wittig sequence, or better through advanced intermediate 9. The carbapenem carboxylateas were chemically unstable; stability was not improved by changing the oxidation state of sulfur.