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Report | Regular issue | Vol 23, No. 8, 1985, pp.1999-2003
Published online, 1st January, 1970
DOI: 10.3987/R-1985-08-1999
Activated Nitriles in Heterocyclic Synthesis: Novel Synthesis of Pyridazines, Pyridines, Pyrazoles and Polyfunctionally Substituted Benzene Derivatives

Galal Eldin Hamza Elgemeie,* Hassan Attia Elfahham, Sherif Elgamal, and Mohamed Hilmy Elnagdi

*Chemistry Department, Faculty of Science, Minia University, Minia, Egypt

Abstract

Knoevenagel condensation of benzoylacetonitrile with malononitrile afforded the corresponding ylidene derivative which could be converted into pyridazine derivative on coupling with benzenediazonium chloride and cyclization. Similarly benzoylacetonitrile underwent self condensation to yield either the benzene derivative or the ylidene derivative. The latter could be converted into a variety of heterocyclic derivatives on reaction with malononitrile, ethyl cyanoacetate, hydrazine hydrate and benzenediazonium chloride.