Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Report | Regular issue | Vol 23, No. 12, 1985, pp.3069-3078
Published online, 1st January, 1970
DOI: 10.3987/R-1985-12-3069
Synthetic Studies of 1-Azapenem

Tomoyuki Shibata, Yukio Sugimura,* Sadao Sato, and Kayoko Kawazoe

*Research Institute, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan


Total synthesis of 1-azapenem (5) is reported. The key intermediate 24 was synthesized by the intramolecular cyclization of 17 and subsequent desilylation. Alkylation of 24 and subsequent hydrogenolysis gave 5.