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Report | Regular issue | Vol 23, No. 12, 1985, pp.3069-3078
Published online, 1st January, 1970
DOI: 10.3987/R-1985-12-3069
Synthetic Studies of 1-Azapenem

Tomoyuki Shibata, Yukio Sugimura,* Sadao Sato, and Kayoko Kawazoe

*Research Institute, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

Abstract

Total synthesis of 1-azapenem (5) is reported. The key intermediate 24 was synthesized by the intramolecular cyclization of 17 and subsequent desilylation. Alkylation of 24 and subsequent hydrogenolysis gave 5.