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Communication | Regular issue | Vol 24, No. 1, 1986, pp.5-7
Published online, 1st January, 1970
DOI: 10.3987/R-1986-01-0005
New Contributions to Protopine Chemistry

Luis Castedo,* Amelia Perelta, Alberto Puga, José M. Saá, and Rafael Suau

*Facultad de Química y Sección de Alcaloides, Deparamento de Química Orgánica, C. S. I. C., Santiago de Compostela, Spain


Protopine undergoes electrophilic aromatic substitution at C-12 by reaction with Br2/HOAc and HNO3/HOAc. Simpler alternative methods for the obtention of dihydrocoptisine and 13-oxycoptisine from protopine are also described.