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Communication | Regular issue | Vol 24, No. 3, 1986, pp.571-574
Published online, 1st January, 1970
DOI: 10.3987/R-1986-03-0571
Efficient Synthesis of (±)-Emetine and (±)-Protoemetinol by the Stereoselective Intramolecular Michael Reaction

Yoshiro Hirai, Atsushi Hagiwara, and TakaoYamazaki*

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan

Abstract

The intramolecular Michael Reaction of 8 and 12 gave stereoselectively 9 and 13, which were converted to the emetine precursor (11) and (±)-protoemetinol (2).