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Communication | Regular issue | Vol 24, No. 3, 1986, pp.607-610
Published online, 1st January, 1970
DOI: 10.3987/R-1986-03-0607
Medelline, First Bisbenzylisoquinoline Alkaloid with a Methylenedioxy Bridge

Diego Cortes, Jairo Saez, Reynald Hocquemiller, André Cavé,* and Adrien Cavé

*Laboratoire de Chimie Therapeutique, Faculte de Pharmacie, Université Paris XI, 5, rue Jean-Baptiste Clément, 92290 Chatenay-Malabry Cedex, France

Abstract

High resolution MS and 1H-NMR studies indicate that medelline, a minor alkaloid isolated from the bark of Pseudoxandra aff. lucida, is the first known example of a bisbenzylisoquinoline alkaloid with a methylenedioxy bridge joining both halves of the molecule. Medelline is probably biosynthesized via intramolecular condensation of the accompanying major bisbenzylisoquinoline alkaloid, antioquine.