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Communication | Regular issue | Vol 24, No. 3, 1986, pp.625-628
Published online, 1st January, 1970
DOI: 10.3987/R-1986-03-0625
Synthesis of N6-(2-Oxopyrrolidin-5-yl)adenosine Derivatives

Yoshiyuki Kosugi,* Tatsuo Nagasaka, Fumiko Hamaguchi, and Sadao Ohki

*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

A convenient method for introducing a pyrrolidinyl moiety into adenosine N6-position by utilizing the acyliminium activity of ω-alkoxylactams is described. Condensation of 5-alkoxy-2-pyrrolidinones (3a-f) and adenosine triacetate followed by deacetylation gave N6-(2-oxopyrrolidin-5-yl)adenosines (6a-f) in good yields.