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Report | Regular issue | Vol 24, No. 3, 1986, pp.647-650
Published online, 1st January, 1970
DOI: 10.3987/R-1986-03-0647
Synthesis and Crystal Structure of Dimethyl N,N’-Diethoxycarbonyl-3,4,7,8-tetrahydro-4,7-phenanthroline-3,8-diphosphonate

Isao Takeuchi, Yasuhiro Shibata, Yoshiki Hamada,* and Masaru Kido

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan

Abstract

Reaction was performed of 4,7-phenanthroline with trimethyl phosphite and ethyl chlorocarbonate in the presence of sodium iodide in acetonitrile as a solvent, to yield dimethyl N,N’-diethoxycarbonyl-3,4,7,8-tetrahydro-4,7-phenanthroline-3,8-diphosphonate (3) and 3,10-diphosphonate (4). 3,8-Diphosphonate (3) was processed in the column chromatogram and was separated into isomers 3a and 3b whose structures were determined by X-ray analysis.