Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Report | Regular issue | Vol 24, No. 4, 1986, pp.943-946
Published online, 1st January, 1970
DOI: 10.3987/R-1986-04-0943
Praziquantel Analogues. I. New and Short Synthesis of 2-Acyl-4-oxo-1,2,3,4,6,7,12,12b-octahydropyrazino[1’,2’:1,2]pyrido[3,4-b]indoles

Nativitat Vallas, Víctor M. Segarra, and Joan Bosch*

*Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. de Joan XXIII, s/n, 08028 Barcelona, Spain

Abstract

A series of potential anthelmintic 2-acyl-4-oxo-1,2,3,4,6,7,12,12b-octahydropyrazino[1’,2’: 1,2]pyrido[3,4-b]indoles has been synthesized in high yield by Pictet-Spengler reaction between tryptamine and the appropriate N-acyl-N-(2,2-diethoxyethyl)glycine ethyl ester.