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Report | Regular issue | Vol 24, No. 4, 1986, pp.943-946
Published online, 1st January, 1970
DOI: 10.3987/R-1986-04-0943
Praziquantel Analogues. I. New and Short Synthesis of 2-Acyl-4-oxo-1,2,3,4,6,7,12,12b-octahydropyrazino[1’,2’:1,2]pyrido[3,4-b]indoles

Nativitat Vallas, Víctor M. Segarra, and Joan Bosch*

*Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. de Joan XXIII, s/n, 08028 Barcelona, Spain


A series of potential anthelmintic 2-acyl-4-oxo-1,2,3,4,6,7,12,12b-octahydropyrazino[1’,2’: 1,2]pyrido[3,4-b]indoles has been synthesized in high yield by Pictet-Spengler reaction between tryptamine and the appropriate N-acyl-N-(2,2-diethoxyethyl)glycine ethyl ester.