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Communication | Regular issue | Vol 24, No. 6, 1986, pp.1517-1525
Published online, 1st January, 1970
DOI: 10.3987/R-1986-06-1517
Synthesis of Vinca Alkaloids and Related Compounds XXX. Total Synthesis of (±)-Tacamine, (±)-Apotacamine, and Their 20-Epimers

Lajos Szabó, Ede Márványos, Gábor Tóth, Csaba Szántay Jr., György Kalaus, and Csaba Szántay*

*Central Research Institute for Chemistry, Hungarian Academy of Sciences, H-1025 Budapest, Pusztaszeri ut 59-67, P.O.Box 17, Hungary

Abstract

Starting from iminium salt 3 two different methods have been elaborated for the synthesis of (±)-tacamine 1, (+)-apotacamine 2 and their 20-epimers .