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Paper | Regular issue | Vol 24, No. 11, 1986, pp.3187-3193
Published online, 1st January, 1970
DOI: 10.3987/R-1986-11-3187
Hofmann Degradation of 2,3-Dihydro-9-phenyl-1H,9H-pyrazolo[1,2-a]indazole Derivatives

Yasuo Fujimura* and Masatomo Hamana

*Central Research Laboratories, Chugai Pharmaceutical Company, Ltd., Takada 3-41-8, Toshima-ku, Tokyo 171, Japan


Treatment of 2,3-dihydro-9-phenyl-1H,9H-pyrazolo[1,2-a]indazoles (2)with alkyl iodides followed by heating with potassium hydroxide solution gave 1-alkyl-6-phenyl-1,2,3,4-tetrahydro-1,5-benzodiazocines (A) and 2-(3-alkylaminopropylamino)benzophenones (B) through the 4-alkyl and the 10-alkyl quaternary salts of 2, respectively.