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Paper | Regular issue | Vol 24, No. 11, 1986, pp.3223-3228
Published online, 1st January, 1970
DOI: 10.3987/R-1986-11-3223
Polycyclic N-Hetero Compounds. XXVIII. Synthesis and Antidepressive Evalution of 4-Substituted 9-Chloro-6,7-dihydro-5H-pyrimido[5,4-d][1]benzazepine

Takashi Hirota,* Masami Fukumoto, and Kenji Sasaki

*Okayama UniversityFaculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan

Abstract

4-Substituted 9-chloro-6,7-dihydro-5H-pyrimido[5,4-d][1]benzazepines (IIIa-j) were synthesized by the reaction of 4,9-dichloro-6,7-dihydro-5H-pyrimido[5,4-d][1]benzazepine (I) with amines (IIa-j) and their antidepressive activities were investigated.