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■ Structure of Mulberrofuran R, a Novel 2-Arylbenzofuran Derivative from the Cultivated Mulberry Tree (Morus lhou Koidz.)

Hideki Kohno, Kazuhiro Takaba, Toshio Fukai, and Taro Nomura

*Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

A novel 2-arylbenzofuran derivative, mulberrofuran R, was isolated from an ethyl acetate extract of the root bark of the cultivated mulberry tree (Roso, a cultivated variety of Morus lhou Koidz.). Its structure was shown to be 1, on the basis of spectral evidence. Mulberrofuran R is regarded biogenetically as a variation of a Diels-Alder type adduct of s chalcone derivative and a dehydroprenyl-2-arylbenzofuran derivative.