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Communication | Regular issue | Vol 26, No. 6, 1987, pp.1455-1460
Published online, 1st January, 1970
DOI: 10.3987/R-1987-06-1455
Studies on the Active Principles from Aconitum flavum Hand-Mazz. The Structures of Five New Deterpenoid Alkaloids

Zhi-gang Chen, Ai-na Lao, Hong-chemg Wang, and Shan-hai Hong

*Shanghai Institute of Material Media, Chinese Academy of Science, 319, Yue-yang Road, Shanghai, 200031, China

Abstract

Reinvestigation of Aconitum flavum Hand-Mazz resulted in the isolation of five new diterpenoid alkaloids, i.e., dehydronapelline (1), 12-acetyllucidusculine (2), 1-epi-napelline (3), 12-epi-napelline (4), and 1-demethylhypaconitine (9), along with napelline, lucidusculine, aconitine, 3-acetylaconitine, deoxyaconitine, flavaconitine, benzoylaconine. and neoline. The structures of these new compounds were determined based on spectral data and chemical transformations. The pharmacological tests showed that 12-acetyllucidusculine (2) has a strong effect of lowering of heart rate in Langendorff’s guinea pig hearts.