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Communication | Regular issue | Vol 26, No. 8, 1987, pp.2053-2056
Published online, 1st January, 1970
DOI: 10.3987/R-1987-08-2053
A Reinvestigation of the Reaction of N-(2-Bromoethyl)isatoic Anhydride with methylamine. Isolation and Crystal Structure of 1-(2-Hydroxyethyl)-3-meethyl-2,4-(1H,3H)-quinazolinedione

Francesco Pinnen, Gino Lucente, Fernando Mazza, and Giorgio Pochetti

*Dipartrimento di Chimica, Instituto di Farmacologia Medica, Università degli Studi di Roma, "La Sapienza", Piazzale Aldo Moro 5, 00185 Roma, Italy


The reaction of N-(2-bromoethyl)isatoic anhydride with methylamine affords 1-(2-hydroxyethyl)-3-methy1-2,4-(1H,3H)-quinazolinedione, the structure of which has been determined by single crystal X-ray diffraction.