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■ The Synthesis of Heptenic Derivatives of Aminoimidazoazaarene Cooked-food Mutagens

Bruce E. Watkins, Mark G. Knize, Chunk J. Morris, Brian D. Andresen, James Happe, Martin Vanderlaan, and James S. Felton

*Lawrence Livermore National Laboratory, Biomedical Sciences Division, University of California, P.O.Box 5507. L-452, Livermore, California 94550, U.S.A.

Abstract

2-N-Aminopropyl derivatives of the food mutagens IQ, MelQx and PhlP were synthesized along with 3-(2-amino-3-methylimidazo[4,5-f]quinoxalin-8-yl) propionic acid. These were used as haptens for the production of monoclonal anlibodies.