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Communication | Regular issue | Vol 26, No. 9, 1987, pp.2355-2359
Published online, 1st January, 1970
DOI: 10.3987/R-1987-09-2355
A One-step Synthesis of Pyrimido[4,5-c]isoquinoline Ring System by Reaction of 6-(N-Methlfurfurymino)uracils with DMAD

Michihiko Noguchi, Seiji Nagata, and Shoji Kajigaeshi

*Department of Applied Chemistry, Faculty of Engineering, Yamaguchi University, 2-16-1 Tokiwadai, Ube, Yamaguchi 755-8611, Japan


Several pyrimido[4,5-c]isoquinoline derivatives were obtained from the reaction of 6-(N-methylfurfurylamino)uracils 1 and DMAD in refluxing ethanol. The formation of the pyrimidoisoquinoline system was due to a sequence of the initial Diels-Alder reaction of the furan moiety of 1 and DMAD, and the successive intramolecular Michael addition.