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Communication | Regular issue | Vol 26, No. 10, 1987, pp.2587-2590
Published online, 1st January, 1970
DOI: 10.3987/R-1987-10-2587
First Synthesis of 1-Trichloromethyl-6,7-dihydroxytetrahydroisoquinoline — An Imaginable Chloral-derived Mammalian Alkaloid

Gerhard Bringmann, Annette Hille, and Marianne Zsiska

*Organisch-Chemisches Institut, Universität Münster, Orleansring 23, D-4400 Münster, Germany

Abstract

1-Trichloromethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (3c), a potential condensation product from dopamine (1) and chloral (2c), could be prepared for the first time, by a stepwise Bischler-Napieralski pathway, and, more directly, under special Pictet-Spengler conditions, The results indicate that 3c is not a probable alkaloid in man.