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Communication | Regular issue | Vol 26, No. 10, 1987, pp.2611-2614
Published online, 1st January, 1970
DOI: 10.3987/R-1987-10-2611
A Novel Synthetic Method of Lactams from1,3-Dioxin-4-ones via Intramorecular Ketene Trapping

Masayuki Sato, Hiromichi Ogasawara, Kazuhisa Takayama, and Chikara Kaneko

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


A novel route to four- and five-membered lactams from 1,3-dioxin-4-ones having an α-aminoalkyl side-chain at 5-or 6-position through cycloreversion to acylketenes followed by intramolecular ketene trapping by the amino function is described.