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Paper | Regular issue | Vol 26, No. 11, 1987, pp.2865-2869
Published online, 1st January, 1970
DOI: 10.3987/R-1987-11-2865
Synthesis of 1-Methyl-2-(2-oxazolyl)-5-nitroimidazole

Abbas Shafiee, Tayebeh Ebrahimi-Bibalan, Mohammad E. Bakhshi-Dezfouli, and Alireza Ghanbarpour

*Department of Chemistry, College of Pharmacy, Tehran University, Tehran 14, Iran


1-Methyl-2-(2-oxazoly1)-5-nitroimidazole (4) was prepared from methyl 1-methyl-5-nitroimidazole-2-carboxylate (5) . The reaction of compound 5 with 2-aminoethanol gave N-(2-hydroxyethy1)-1-methyl-5-nitroimidazole-2-carboxamide (7). Treatment of 7 with thionyl chloride gave 8 which was cyclized to afford 9 by treatment with a base. Oxidation of 9 with nickel peroxide afforded compound 4.