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Communication | Regular issue | Vol 26, No. 12, 1987, pp.3081-3083
Published online, 1st January, 1970
DOI: 10.3987/R-1987-12-3081
Intramolecular Cyclizations of Hantzsch 1,4-Dihydropyridines: Synthesis of Di- and Tetrahydroindeno[2,1-c]pyridines

Steven D. Young, Stella W. King, and David C. Remy

*Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486, U.S.A.


Hantzsch 4-phenyl-1,4-dihydropyridines bearing electrophilic ortho substituents react with trimethylsilyl cyanide/zinc iodide or base resulting in an intramolecular cyclization reaction to give di-and tetrahydroindeno[2,1-c]pyridines in good yield.