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■ Syntheses of 1,4-Oxazepines, 1,4-Diazepines, and Their 5-Oxo Derivatives from 2-Pyridones

Jyoji Kurita, Takeharu Yoneda, Naoki Kakusawa, and Takashi Tsuchiya

*School of Pharmacy, Hokuriku University, 3-Ho, Kanagawa machi, Kanazawa 920-1181, Japan

Abstract

Thermolysis of the 3-aza-7-oxa- (11) and 3,7-diaza-4-oxotricyclo[4.1.0.0^2,5]heptanes (12), prepared from 2-pyridones via four steps, resulted in valence isomerization with ring opening to give the novel 1,4-oxazepin-5-ones (14) and 1,4-diazepin-5-ones N (15), respectively, which were treated with triethyloxonium tetrafluoroborate to afford the fully unsaturated 1,4-oxazepines (16) and 1,4-diazepines (17), respectively.