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Communication | Regular issue | Vol 26, No. 12, 1987, pp.3089-3092
Published online, 1st January, 1970
DOI: 10.3987/R-1987-12-3089
Electrophilic ipso-Substitution of 5-Bromouridines with Diaryl Disulfides. Novel Synthesis of 5-Arylthiouridines

Kosaku Hirota, Tetsuo Tomishi, and Yoshifumi Maki

*Labolatory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


Reaction of 5-bromo-2’,3’-O-isopropylideneuridine (1) with diaryl disulfides in the presence of base induced an electrophilic ispo-substitution to give 5-arylthiouridine derivatives (2).