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Communication | Regular issue | Vol 26, No. 12, 1987, pp.3111-3114
Published online, 1st January, 1970
DOI: 10.3987/R-1987-12-3111
Studies of as-Triazine Derivatives. X. Addition Reaction of Phenylmagnesium Bromide with 1,2,4-Triazines

Shoetsu Konno, Mataichi Sagi, Nobuko Yoshida, and Hiroshi Yamanaka

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

The reaction of 1,2,4-triazine with phenylmagnesium bromide was investigated. Every position of 3, 5, and 6 in a 1,2,4-triazine ring is active in the addition reaction of Grignard reagents. Since 5-phenyl-1,2,4-triazine, 5,6-diphenyl-1,2,4-triazine, and 3,5,6-triaryl-1,2,4-triazine were obtained subsequently, it was comfirmed that the most active position was position 5 and the least active one was position 3.