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■ Definite Total Synthesis of Coumarinolignans, Daphneticin and Its Regioisomer

Hitoshi Tanaka, Masaya Ishijara, Kazuhiko Ichino, and Kazuo Ito

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan

Abstract

The synthesis of 7-benzyloxy-8-hydroxycoumarin (5) and 8-benzyloxy-7-hydroxycoumarin (11) was described and further, by use of 5 as a starting material, daphneticin (1) was synthesized. On the other hand, its regioisomer (2) was also synthesized from (8), readily prepared via two steps from 5, according to the method described in the synthesis of daphneticin.