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■ An Improved Synthesis of 1-Alkyl-4-imidazolin-2-ones

Ooi Wong, Noriko Tsuzuki, Mark Richardson, Howard Rytting, Ryoji Konishi, and Takeru Higuchi

*Department of Pharmaceutical Chemistry, University of Kansas, 4070 Malott Hall, Lawrence, Kansas 66045-2506, U.S.A.

Abstract

Two 1-alkyl-4-imidazolin-2-ones were prepared by acid-catalysed cyclization of N-(2,2-dialkoxyethyl)-N-alkylureas, with improved yields of over 90%. The amount of HC1 used in the reaction and the proper isolation procedure are the important factors in obtaining the high yields.