Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 26, No. 12, 1987, pp.3193-3196
Published online, 1st January, 1970
DOI: 10.3987/R-1987-12-3193
A Facile Preparation of 3-Substituted 2-Thioxo-tetrahydoquinazolin-4-ones by the Reaction of Anthranilamide with Isothiocynates

Chao-Han Chan, Fang-Jy Shish, Kang-Chien Liu, and Ji-Wang Chern

*Medical Laboratories and Institute of Pharmacy, National Defense Medical Center, P.O. Box 90048-512, Taipei, Taiwan, R.O.C.


3-Substituted 2-thioxa-tetrahydroquinazolin-4-ones (4a-d) can be synthesized in a convenient procedure directly by a treatment of anthranilemide with isothiocyanates at room temperature. However, anthranilamide was reacted with 4-isothiocyanato-1-benzylpiperidme (2e) leading to the formation of 2-[3-(1-benzyl-4-piperidinyl)]thioureidobenzarnide (3e) which was subsequently cyclized to 4e under a basic condition.