HETEROCYCLES

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■ Polycyclic N-Hetero Compounds. XXX. Synthesis and Antidepressive Evaluation of 3-Substituted 3,4,5,6-Tetrahydrobenzo[h]quinazolin-4-ones

Takashi Hirota, Kenji Sasaki, Hiroshi Yamamoto, and Takashi Katsu

*Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan

Abstract

Syntheeis of 3-substituted 3,4,5,6-tetrehydrohenzo[h]-quinaeolin-4-ones is described. Antidepressive evaluation of these compounds was performed by antireserpine action and compounds IX and X exhibited the positive action.