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Review | Regular issue | Vol 57, No. 8, 2002, pp.1539-1553
Published online, 1st January, 1970
DOI: 10.3987/REV-02-551
Polyhydroxylated Alkaloids with Lipophilic Moieties as Glycosidase Inhibitors from Higher Plants

Makio Shibano, Daisuke Tsukamoto, and Genjiro Kusano*

*Faculty of Pharmaceutical Science, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

Abstract

Two new types of polyhydroxylated alkaloids, broussonetines and radicamines, which have an aliphatic or an aromatic moiety, were isolated from Broussonetia kazinoki (Moraceae) and Lobelia chinensis (Campanulaceae), respectively, as glycosidase inhibitors. Feeding experiments using [1-13C] glucose and 13C-NMR spectroscopic studies showed that broussonetines are biosynthesized through routes similar to those of sphingosine and phytosphingosine.