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Review | Special issue | Vol 66, No. 1, 2005, pp.727-741
Published online, 1st November, 2005
DOI: 10.3987/REV-05-SR(K)3
Synthetic Strategies of Fostriecin

Masakatsu Shibasaki* and Motomu Kanai

*Faculty of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan


Fostriecin is a naturally occurring triene-containing phosphate ester, which exhibits a potent and selective PP2A inhibitory activity. Due to its interesting chemical structure and biological activity, strategically unique total syntheses of fostriecin were reported from several groups. An overview of the synthesis and chemistry-based structure-activity relationships of fostriecin is described in this review.