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Review | Regular issue | Vol 75, No. 9, 2008, pp.2133-2153
Published online, 7th March, 2008
DOI: 10.3987/REV-07-626
Palladium(II)-Catalyzed Cyclization via N-Alkylation of an Allyl Alcohol with a Urethane and Its Application to the Syntheses of Natural Products

Hajime Yokoyama and Yoshiro Hirai*

*University of Toyama, Graduate School of Science and Engineering, 3190 Gofuku, Toyama 930-8555, Japan

Abstract

Stereoselective amino-palladation of alkenylamines is one of the most important approaches for the stereoselective construction of N-hetero-alicycles, which form the skeletons of several biologically active natural products and related compounds. We reviewed our work with the utility of palladium(II)-catalyzed cyclization via N-alkylation of an allyl alcohol with a urethane. The syntheses of natural products by using Pd(II)-catalyzed cyclization were also reviewed.