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Review | Special issue | Vol 74, No. 1, 2007, pp.125-143
Published online, 22nd November, 2007
DOI: 10.3987/REV-07-SR(W)5
Survey of Chemical Syntheses of the Pyrrolizidine Alkaloids Turneforcidine and Platynecine

John A. Vanecko and Frederick G. West*

*Gunning/Lemieux Chemistry Center, Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada

Abstract

The necine bases turneforcidine and platynecine have inspired a great deal of synthetic effort. Key challenges include the construction of the bicyclic pyrrolizidine ring system and controlled introduction of three contiguous stereocenters. This review will survey the many diverse strategies by which these natural products have been synthesized.