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Review | Regular issue | Vol 75, No. 7, 2008, pp.1575-1622
Published online, 22nd February, 2008
DOI: 10.3987/REV-08-629
Pyrazolo[1,5-a][1,3,5]triazines(5-Aza-9-deazapurines): Synthesis and Biological Activity

Anton V. Dolzhenko, Anna V. Dolzhenko, and Wai-Keung Chui*

*Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore

Abstract

The present review gives an account on the synthetic routes to pyrazolo[1,5-a][1,3,5]triazine system, which is an isostere of purine, and polyfused systems bearing this heterocyclic core. Data concerning biological activity of compounds with pyrazolo[1,5-a][1,3,5]triazine skeleton are also discussed.