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Review | Regular issue | Vol 34, No. 11, 1992, pp.2143-2177
Published online, 1st January, 1970
DOI: 10.3987/REV-92-446
Recent Advances in the Synthesis of Antibacterial Quinolones

Stanislav Radl* and Daniel Bouzard

*Hoffmann-La Roche, Inc., 340 Kingsland Street, Nutley, N. J. 07110, U.S.A.

Abstract

This review surveys the main synthetic approaches used for the construction of antibacterial quinolones, including aza analogs (naphthyridones, cinnolones) and condensed polycyclic analogs, with an emphasis on the more versatile methods which are potentially useful in other fields of heterocyclic chemistry. Simpler non-condensed monocyclic analogs, i.e., pyridone and pyridainone carboxylic acids are also briefly mentioned.